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2002 1
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miR-216b suppresses breast cancer growth and metastasis by targeting SDCBP.
Jana S, Sengupta S, Biswas S, Chatterjee A, Roy H, Bhattacharyya A. Jana S, et al. Biochem Biophys Res Commun. 2017 Jan 1;482(1):126-133. doi: 10.1016/j.bbrc.2016.10.003. Epub 2016 Oct 5. Biochem Biophys Res Commun. 2017. PMID: 27720715
However the post transcriptional regulation of SDCBP overexpression remains to be an unexplored area. Our study reveals that miR-216b directly regulates SDCBP expression by binding to its 3'UTR region. miR-216b is a tumor suppressive miRNA and it is underexpressed d …
However the post transcriptional regulation of SDCBP overexpression remains to be an unexplored area. Our study reveals that miR-216b …
SDCBP promotes pancreatic cancer progression by preventing YAP1 from beta-TrCP-mediated proteasomal degradation.
Liu J, Bai W, Zhou T, Xie Y, Yang B, Sun J, Wang Y, Li X, Hou X, Liu Z, Fu D, Yan J, Jiang W, Zhao K, Zhou B, Yuan S, Guo Y, Wang H, Chang A, Gao S, Shi L, Huang C, Yang S, Hao J. Liu J, et al. Gut. 2023 Sep;72(9):1722-1737. doi: 10.1136/gutjnl-2022-327492. Epub 2023 Feb 24. Gut. 2023. PMID: 36828627
RESULTS: The median overall survival and recurrence-free survival rates in the high-SDCBP group were significantly shorter than those in the low-SDCBP group. ...SDCBP interacts with the TAD domain of YAP1, mainly through its PDZ1 domain. ...
RESULTS: The median overall survival and recurrence-free survival rates in the high-SDCBP group were significantly shorter than those …
Dasatinib inhibits c-src phosphorylation and prevents the proliferation of Triple-Negative Breast Cancer (TNBC) cells which overexpress Syndecan-Binding Protein (SDCBP).
Qian XL, Zhang J, Li PZ, Lang RG, Li WD, Sun H, Liu FF, Guo XJ, Gu F, Fu L. Qian XL, et al. PLoS One. 2017 Jan 31;12(1):e0171169. doi: 10.1371/journal.pone.0171169. eCollection 2017. PLoS One. 2017. PMID: 28141839 Free PMC article.
Triple negative breast cancer (TNBC) progresses rapidly but lacks effective targeted therapies. ...SDCBP-overexpressing MDA-MB-231 cells were then constructed to evaluate the effects of dasatinib on SDCBP-induced TNBC progression in vitro and tumor formation …
Triple negative breast cancer (TNBC) progresses rapidly but lacks effective targeted therapies. ...SDCBP-overexpressing MDA-MB …
MDA-9/Syntenin/SDCBP: new insights into a unique multifunctional scaffold protein.
Pradhan AK, Maji S, Das SK, Emdad L, Sarkar D, Fisher PB. Pradhan AK, et al. Cancer Metastasis Rev. 2020 Sep;39(3):769-781. doi: 10.1007/s10555-020-09886-7. Cancer Metastasis Rev. 2020. PMID: 32410111 Free PMC article. Review.
Melanoma differentiation associated gene-9 (mda-9) (also known as Syntenin-1 and SDCBP (Syndecan binding protein)) was identified by subtraction hybridization as a novel gene displaying differential temporal expression during differentiation of melanoma. ...Expression of M …
Melanoma differentiation associated gene-9 (mda-9) (also known as Syntenin-1 and SDCBP (Syndecan binding protein)) was identified by …
Repression of miR-135b-5p promotes metastasis of early-stage breast cancer by regulating downstream target SDCBP.
Pu T, Shen M, Li S, Yang L, Gao H, Xiao L, Zhong X, Zheng H, Liu Y, Ye F, Bu H. Pu T, et al. Lab Invest. 2019 Sep;99(9):1296-1308. doi: 10.1038/s41374-019-0258-1. Epub 2019 Apr 25. Lab Invest. 2019. PMID: 31024042 Free article.
We also validated a novel target gene for miR-135b-5p, syndecan binding protein (SDCBP), and assessed the functional consequences of SDCBP by invasion assays. ...Interestingly, silencing SDCBP can reverse miR-135b-5p-dependent EMT and proliferation. In vivo s …
We also validated a novel target gene for miR-135b-5p, syndecan binding protein (SDCBP), and assessed the functional consequences of …
MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor beta1 to enhance epithelial-mesenchymal transition in breast cancer.
Menezes ME, Shen XN, Das SK, Emdad L, Sarkar D, Fisher PB. Menezes ME, et al. Oncotarget. 2016 Dec 6;7(49):80175-80189. doi: 10.18632/oncotarget.13373. Oncotarget. 2016. PMID: 27863394 Free PMC article.
However, the molecular mechanisms underlying this transition require further clarification. MDA-9/syntenin (SDCBP) expression is elevated in breast cancer patient samples as well as cultured breast cancer cells. ...Our findings provide evidence for the releva …
However, the molecular mechanisms underlying this transition require further clarification. MDA-9/syntenin (SDCBP) expression is elev …
Syndecan binding protein (SDCBP) is overexpressed in estrogen receptor negative breast cancers, and is a potential promoter for tumor proliferation.
Qian XL, Li YQ, Yu B, Gu F, Liu FF, Li WD, Zhang XM, Fu L. Qian XL, et al. PLoS One. 2013;8(3):e60046. doi: 10.1371/journal.pone.0060046. Epub 2013 Mar 22. PLoS One. 2013. PMID: 23533663 Free PMC article.
METHODOLOGY/PRINCIPAL FINDINGS: We first evaluated the SDCBP expression by immunohistochemistry in normal breast and BCa tissues. ...SDCBP expression was detected in 80.6% (n = 160) of BCa tissues, in contrast to its expression in 13% (n = 23) of normal br …
METHODOLOGY/PRINCIPAL FINDINGS: We first evaluated the SDCBP expression by immunohistochemistry in normal breast and BCa tissu …
Syntenin1/MDA-9 (SDCBP) induces immune evasion in triple-negative breast cancer by upregulating PD-L1.
Liu J, Yang Y, Wang H, Wang B, Zhao K, Jiang W, Bai W, Liu J, Yin J. Liu J, et al. Breast Cancer Res Treat. 2018 Sep;171(2):345-357. doi: 10.1007/s10549-018-4833-8. Epub 2018 May 29. Breast Cancer Res Treat. 2018. PMID: 29845474
PURPOSE: Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. However, the role of syntenin1 in triple-negative br …
PURPOSE: Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domai …
Inhibition of endoplasmic reticulum stress alleviates triple-negative breast cancer cell viability, migration, and invasion by Syntenin/SOX4/Wnt/beta-catenin pathway via regulation of heat shock protein A4.
Nan J, Hu X, Guo B, Xu M, Yao Y. Nan J, et al. Bioengineered. 2022 Apr;13(4):10564-10577. doi: 10.1080/21655979.2022.2062990. Bioengineered. 2022. PMID: 35442158 Free PMC article.
The data indicate that the ability of viability and metastasis of breast cancer cells were stronger than normal mammary epithelial cells. More aggressiveness was manifested in TNBC cells than that in non-TNBC cells. 4-PBA significantly suppressed the viability, migration, …
The data indicate that the ability of viability and metastasis of breast cancer cells were stronger than normal mammary epithelial ce …
Targeting tumor invasion: the roles of MDA-9/Syntenin.
Kegelman TP, Das SK, Emdad L, Hu B, Menezes ME, Bhoopathi P, Wang XY, Pellecchia M, Sarkar D, Fisher PB. Kegelman TP, et al. Expert Opin Ther Targets. 2015 Jan;19(1):97-112. doi: 10.1517/14728222.2014.959495. Epub 2014 Sep 15. Expert Opin Ther Targets. 2015. PMID: 25219541 Free PMC article. Review.
16 results